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KMID : 1098420140220020098
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Korean Journal of Medicinal Crop Science
2014 Volume.22 No. 2 p.98 ~ p.104
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Inhibitory Effect of Alopecurus aequalis Sobol Ethanol Extracts on LPS-induced Inflammatory Response in RAW 264.7 Cells
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Jung Ho-Kyung
Kang Byoung-Man
Jang Ji-Hun
Ahn Byung-Kwan
Yeo Jun-Hwan
Jung Won-Seok
Cho Jung-Hee
Kuk Yong-In
Hyun Kyu-Hawn
Cho Hyun-Woo
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Abstract
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In the present study, we investigated the anti-inflammatory effects by Alopecurus aequalis Sobol on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production by RAW 264.7 cell line. Consistent with these observations, DS reduced the LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the protein levels in a concentration-dependent manner. In addition, the release of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were also reduced by DS. Moreover, LPS increased expression phosphorylation of IκBα, but DS showed inhibitory effect by reducing LPS-inducible p-IκBα expression level. These results suggest that the down regulation of iNOS, COX-2, TNF-α, and IL-6 expression by DS are achieved by the downregulation of NF-κB activity, a transcription factor necessary for pro-inflammatory mediators, and that is also responsible for its anti-inflammatory effects.
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KEYWORD
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Alopecurus aequalis Sobol, Inflammation, RAW 264.7 Cell Line, Lipopolysaccharide
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